Intraepithelial carcinoma (Bowen disease)
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የተለመደ ጉዳይ - Intraepithelial carcinoma (Bowen disease) ለረጅም ጊዜ የሚቆይ የማይከሰት ኤክማ ተብሎ ሊታወቅ ይችላል።
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ReferencesBowen's disease (BD) ከቆዳው ውጫዊ ክፍል (ኤፒደርሚስ) የሚጀምር የቆዳ ካንሰር አይነት ነው። በካውካሰስ ውስጥ በጣም የተለመደ ነው እና ብዙ ጊዜ ለፀሐይ ብርሃን በተጋለጡ አካባቢዎች ይከሰታል፣ ነገር ግን ሌላ ቦታም ሊታይ ይችላል። BD በተለምዶ እንደ ነጠላ ቁስል ይታያል። BD ብዙ ጊዜ ይበልጥ አሳሳቢ የሆነ የቆዳ ካንሰር ከመፈጠሩ በፊት ማስጠንቀቂያ ምልክት ይሆናል። ቢዲ (BD) ን ለማረጋገጥ ዶክተሮች አብዛኛውን ጊዜ ቲሹ ናሙናዎችን በአጉሊ መነጽር (ባዮፕሲ) በመለያየት ይተማማናሉ።
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease በአብዛኛው እድሜያቸው ከ 60 ዓመት በላይ የሆኑ ሰዎችን ይጎዳል። ቁልፍ ተጋላጭነት ምክንያቶች ለረጅም ጊዜ ፀሐይ ተጋልባችን፣ የበሽታ መከላከያ ኃይል እንደተቀነሰ፣ የአርሴኒክ ተጋላጭነት እና የቆዳ HPV ኢንፌክሽን ያካትታሉ። HPV ዝርያዎች 16፣ 18፣ 34 እና 48 ከቦወን በሽታ ጋር በብልት አካባቢ ይገናኛሉ። HPV ብልት አይደለም የሚሉት ጉዳዮች ላይ ያለው ተሳትፎ ብዙ ግልጽ ነው።
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
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